E-ISSN 2576-3288
 

Original Research (Original Article) 


ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed.

Abstract
Introduction: Environmental exposure to nanoparticles is inevitable as they became part of our daily life. Nanoparticles are widely distributed in air, cosmetics and medicines and even in food and as a result, nanotoxicity research is gaining attention. Gold nanoparticles (AuNPs) can cause lung damage through increased oxidative stress. Melatonin has a huge protective effect on all organs of the body through regulation of antioxidant enzymes.

Objective: in the present study we examined the possible histological alterations in the pulmonary alveoli after administration of 10 nm AuNPs in an attempt to understand the toxicity of AuNPs and the possible protective effect of concomitant administration of melatonin.

Material & methods: 30 healthy adult male albino rats were used. They were divided into 3 groups; control group (10 animals), AuNPs group: 10 animals treated with 4 mg/kg of 10 nm AuNPs once daily for 7 consecutive days and AuNPs+melatonin group: 10 rats treated with 4mg/kg of 10 nm AuNPs and 10 mg/kg melatonin at the same time once daily for 7 consecutive days.

Results: Exposure to AuNPs induced alterations in the pulmonary alveoli which were summarized mainly as destruction of type 1and type 2 pneumocytes, thick interalveolar septa due to cellular infiltration. There was mild affection of pulmonary alveoli in the AuNPs+melatonin group; few alveoli appeared slightly collapsed, separated by slightly thickened interalveolar septa due to mild cellular infiltration.

Conclusion: AuNPs induced evident damage in rat pulmonary alveoli. Melatonin significantly ameliorated the alveolar damage.

Key words: AuNPs, Melatonin, Pulmonary alveoli, Nanotoxicity, Oxidative stress.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ehab Mostafa Elzawawy
Articles by Abeer Gaber Ahmed
on Google
on Google Scholar
Article Statistics
 Viewed: 1253
Downloaded: 443
Cited: 0

How to Cite this Article
Pubmed Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed. ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.. Am J Res Med Sci. 2018; 2(1): 24-33. doi:10.5455/ajrms.281645


Web Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed. ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.. http://www.ajrms.com/?mno=281645 [Access: December 09, 2018]. doi:10.5455/ajrms.281645


AMA (American Medical Association) Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed. ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.. Am J Res Med Sci. 2018; 2(1): 24-33. doi:10.5455/ajrms.281645



Vancouver/ICMJE Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed. ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.. Am J Res Med Sci. (2018), [cited December 09, 2018]; 2(1): 24-33. doi:10.5455/ajrms.281645



Harvard Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed (2018) ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.. Am J Res Med Sci, 2 (1), 24-33. doi:10.5455/ajrms.281645



Turabian Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed. 2018. ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.. American Journal of Research in Medical Sciences, 2 (1), 24-33. doi:10.5455/ajrms.281645



Chicago Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed. "ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.." American Journal of Research in Medical Sciences 2 (2018), 24-33. doi:10.5455/ajrms.281645



MLA (The Modern Language Association) Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed. "ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.." American Journal of Research in Medical Sciences 2.1 (2018), 24-33. Print. doi:10.5455/ajrms.281645



APA (American Psychological Association) Style

Ehab Mostafa Elzawawy, Abeer Gaber Ahmed (2018) ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.. American Journal of Research in Medical Sciences, 2 (1), 24-33. doi:10.5455/ajrms.281645





Most Viewed Articles
  • Juvenile rectal polyp with osseous metaplasia- A rare case report.
    Sonam S Nandyal, Krishnamurthy P Shashikala, Lakmapur Math Manjunath
    Am J Res Med Sci. 2017; 1(1): 35-37
    » Abstract » doi: 10.5455/ajrms.281681

  • Primary Intracranial Myxoid Chondrosarcoma: A case report
    Hayam E. Rashed, Aziza E. Abdelrahman, Wael Elmesallamy, Ahmed A.E. Obaya
    Am J Res Med Sci. 2018; 2(1): 44-47
    » Abstract » doi: 10.5455/ajrms.281691

  • Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats
    Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare
    Am J Res Med Sci. 2017; 1(1): 8-13
    » Abstract » doi: 10.5455/ajrms.281722

  • Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats
    Oluwatobi T Somade, Regina N Ugbaja, Abdullahi A Adebayo
    Am J Res Med Sci. 2017; 1(1): 27-34
    » Abstract » doi: 10.5455/ajrms.281388

  • Study of Keratinocyte Proliferation, Apoptosis and Dermal Inflammation in Psoriatic Skin Lesions Before and After Methotrexate Therapy: Which Change Is Contributing More to Clinical Severity of the Disease?
    Amany Abdel Bary, Ahmed Abdel Bary
    Am J Res Med Sci. 2018; 2(1): 34-43
    » Abstract » doi: 10.5455/ajrms.281926

  • ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.
    Ehab Mostafa Elzawawy, Abeer Gaber Ahmed
    Am J Res Med Sci. 2018; 2(1): 24-33
    » Abstract » doi: 10.5455/ajrms.281645

  • Organ-Specific Effects of Selenium Glutathione Peroxidases in Response to Medicinal Plant Extracts
    Janka Vašková, Gabriela Moj& 382;išová, Ladislav Vaško, Michal Stanko, Janka Porá& 269;ová
    Am J Res Med Sci. 2018; 2(1): 1-8
    » Abstract » doi: 10.5455/ajrms.281449

  • Bioactive compounds in Costus afer Ker Gawl leaves and stem fractions protect against calcium ion-induced mitochondrial membrane permeability transition
    Godswill N. Anyasor, Efemena E. Obukohwo, Olanipekun O. Adenike
    Am J Res Med Sci. 2017; 1(1): 21-26
    » Abstract » doi: 10.5455/ajrms.281653

  • Relevance of a new HPLC assay for 4-hydroxy-2-nonenal in human plasma
    Andrea Bolner, Ottavio Bosello, Giampietro Nordera
    Am J Res Med Sci. 2017; 1(1): 1-7
    » Abstract » doi: 10.5455/ajrms.281669

  • Antioxidant evaluation and inhibitory activity of Chromolaena odorata leaf extract on hydrogen peroxide-induced erythrocyte hemolysis
    Angela Nwachukwu, Chioma Peace Iyagbo, Juliet Nneoma Onyenweaku, Tebekeme Okoko
    Am J Res Med Sci. 2018; 2(1): 17-23
    » Abstract » doi: 10.5455/ajrms.281421

  • Most Downloaded
  • Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats
    Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare
    Am J Res Med Sci. 2017; 1(1): 8-13
    » Abstract » doi: 10.5455/ajrms.281722

  • Primary Intracranial Myxoid Chondrosarcoma: A case report
    Hayam E. Rashed, Aziza E. Abdelrahman, Wael Elmesallamy, Ahmed A.E. Obaya
    Am J Res Med Sci. 2018; 2(1): 44-47
    » Abstract » doi: 10.5455/ajrms.281691

  • ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.
    Ehab Mostafa Elzawawy, Abeer Gaber Ahmed
    Am J Res Med Sci. 2018; 2(1): 24-33
    » Abstract » doi: 10.5455/ajrms.281645

  • Study of Keratinocyte Proliferation, Apoptosis and Dermal Inflammation in Psoriatic Skin Lesions Before and After Methotrexate Therapy: Which Change Is Contributing More to Clinical Severity of the Disease?
    Amany Abdel Bary, Ahmed Abdel Bary
    Am J Res Med Sci. 2018; 2(1): 34-43
    » Abstract » doi: 10.5455/ajrms.281926

  • An in vitro screening study of food functions among vegetable cultivars consumed in Japan
    Naoki Ohkura, Riko Fujita, Ruri Kanai, Kenichi Ishibashi, Hiroshi Ueda, Gen-ichi Atsumi
    Am J Res Med Sci. 2018; 3(1): 1-6
    » Abstract » doi: 10.5455/ajrms.20180126090406

  • Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats
    Oluwatobi T Somade, Regina N Ugbaja, Abdullahi A Adebayo
    Am J Res Med Sci. 2017; 1(1): 27-34
    » Abstract » doi: 10.5455/ajrms.281388

  • Acute and sub-chronic oral toxicity studies on the methanol leaf extract of Gnetum africanum Welw in wistar rats.
    Nkeiruka Emmanuela Udeh, Aruh Anaga, Isaac Uzoma Asuzu
    Am J Res Med Sci. 2018; 3(1): 7-14
    » Abstract » doi: 10.5455/ajrms.20180109094114

  • Organ-Specific Effects of Selenium Glutathione Peroxidases in Response to Medicinal Plant Extracts
    Janka Vašková, Gabriela Moj& 382;išová, Ladislav Vaško, Michal Stanko, Janka Porá& 269;ová
    Am J Res Med Sci. 2018; 2(1): 1-8
    » Abstract » doi: 10.5455/ajrms.281449

  • Antioxidant evaluation and inhibitory activity of Chromolaena odorata leaf extract on hydrogen peroxide-induced erythrocyte hemolysis
    Angela Nwachukwu, Chioma Peace Iyagbo, Juliet Nneoma Onyenweaku, Tebekeme Okoko
    Am J Res Med Sci. 2018; 2(1): 17-23
    » Abstract » doi: 10.5455/ajrms.281421

  • Paracetamol and Hydrogen peroxide-induced tissue alterations are reduced by Costus afer extract
    Tebekeme Okoko
    Am J Res Med Sci. 2018; 2(2): 66-72
    » Abstract » doi: 10.5455/ajrms.20171230100944

  • Most Cited Articles