E-ISSN 2576-3288
 

Original Research (Original Article) 


Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare.

Abstract
Objective: Obesity is an important, multifaceted chronic disorder which has become one of the leading health problems globally as a result of its morbidity and mortality. The aim of this research was to induce obesity using high fat diet feeding and to assess the effect of treatment with antioxidant rich nutraceuticals in the pathology of the liver, kidney and heart.
Methods: Nutraceuticals were formulated using locally available foodstuffs (onions, garlic, tomatoes, lemon, palm oil and crayfish in the ratio of 5:5:2:4:2:2) based on recommended daily allowances (RDA). Obesity was induced using high fat diet feeding for ten weeks. Wistar rats of both sexes weighing 150-220 g were used for the study. The animals were grouped into 4 group of 8 rats each: group I: normal, control; group II: high fat diet, untreated; group III: high fat diet treated with 250 mg of nutraceutical daily; group IV: high fat diet treated with 500 mg of nutraceutical daily for ten weeks. Sections of liver, kidney and heart were taken for histopathological study.
Results: The data obtained showed that high fat diet feeding significantly increased body mass and body mass index and was associated with an abnormal lipid distribution. Histopathological examination showed that high fat diet feeding was associated with hepatic, myocardial and renal necrosis, degeneration and congestion of associated blood vessels. However, treatment with antioxidant rich nutraceutical reverses the damage to near normal.
Conclusion: High fat diet induced obesity is associated with pathological changes in the heart, kidney and liver. Antioxidant rich nutraceuticals could provide a protective effect against pathological changes in obesity.

Key words: Body mass index, high fat diet, obesity, nutraceuticals


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Suleiman A. Isa
Articles by Muazu G. Abubakar
Articles by Muhammed S. Abubakar
Articles by Muhammad A. Ubana
Articles by Abdullahi Dandare
on Google
on Google Scholar
Article Statistics
 Viewed: 1284
Downloaded: 449
Cited: 0

How to Cite this Article
Pubmed Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare. Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats. Am J Res Med Sci. 2017; 1(1): 8-13. doi:10.5455/ajrms.281722


Web Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare. Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats. http://www.ajrms.com/?mno=281722 [Access: December 09, 2018]. doi:10.5455/ajrms.281722


AMA (American Medical Association) Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare. Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats. Am J Res Med Sci. 2017; 1(1): 8-13. doi:10.5455/ajrms.281722



Vancouver/ICMJE Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare. Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats. Am J Res Med Sci. (2017), [cited December 09, 2018]; 1(1): 8-13. doi:10.5455/ajrms.281722



Harvard Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare (2017) Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats. Am J Res Med Sci, 1 (1), 8-13. doi:10.5455/ajrms.281722



Turabian Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare. 2017. Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats. American Journal of Research in Medical Sciences, 1 (1), 8-13. doi:10.5455/ajrms.281722



Chicago Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare. "Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats." American Journal of Research in Medical Sciences 1 (2017), 8-13. doi:10.5455/ajrms.281722



MLA (The Modern Language Association) Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare. "Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats." American Journal of Research in Medical Sciences 1.1 (2017), 8-13. Print. doi:10.5455/ajrms.281722



APA (American Psychological Association) Style

Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare (2017) Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats. American Journal of Research in Medical Sciences, 1 (1), 8-13. doi:10.5455/ajrms.281722





Most Viewed Articles
  • Juvenile rectal polyp with osseous metaplasia- A rare case report.
    Sonam S Nandyal, Krishnamurthy P Shashikala, Lakmapur Math Manjunath
    Am J Res Med Sci. 2017; 1(1): 35-37
    » Abstract » doi: 10.5455/ajrms.281681

  • Primary Intracranial Myxoid Chondrosarcoma: A case report
    Hayam E. Rashed, Aziza E. Abdelrahman, Wael Elmesallamy, Ahmed A.E. Obaya
    Am J Res Med Sci. 2018; 2(1): 44-47
    » Abstract » doi: 10.5455/ajrms.281691

  • Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats
    Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare
    Am J Res Med Sci. 2017; 1(1): 8-13
    » Abstract » doi: 10.5455/ajrms.281722

  • Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats
    Oluwatobi T Somade, Regina N Ugbaja, Abdullahi A Adebayo
    Am J Res Med Sci. 2017; 1(1): 27-34
    » Abstract » doi: 10.5455/ajrms.281388

  • Study of Keratinocyte Proliferation, Apoptosis and Dermal Inflammation in Psoriatic Skin Lesions Before and After Methotrexate Therapy: Which Change Is Contributing More to Clinical Severity of the Disease?
    Amany Abdel Bary, Ahmed Abdel Bary
    Am J Res Med Sci. 2018; 2(1): 34-43
    » Abstract » doi: 10.5455/ajrms.281926

  • ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.
    Ehab Mostafa Elzawawy, Abeer Gaber Ahmed
    Am J Res Med Sci. 2018; 2(1): 24-33
    » Abstract » doi: 10.5455/ajrms.281645

  • Organ-Specific Effects of Selenium Glutathione Peroxidases in Response to Medicinal Plant Extracts
    Janka Vašková, Gabriela Moj& 382;išová, Ladislav Vaško, Michal Stanko, Janka Porá& 269;ová
    Am J Res Med Sci. 2018; 2(1): 1-8
    » Abstract » doi: 10.5455/ajrms.281449

  • Bioactive compounds in Costus afer Ker Gawl leaves and stem fractions protect against calcium ion-induced mitochondrial membrane permeability transition
    Godswill N. Anyasor, Efemena E. Obukohwo, Olanipekun O. Adenike
    Am J Res Med Sci. 2017; 1(1): 21-26
    » Abstract » doi: 10.5455/ajrms.281653

  • Relevance of a new HPLC assay for 4-hydroxy-2-nonenal in human plasma
    Andrea Bolner, Ottavio Bosello, Giampietro Nordera
    Am J Res Med Sci. 2017; 1(1): 1-7
    » Abstract » doi: 10.5455/ajrms.281669

  • Antioxidant evaluation and inhibitory activity of Chromolaena odorata leaf extract on hydrogen peroxide-induced erythrocyte hemolysis
    Angela Nwachukwu, Chioma Peace Iyagbo, Juliet Nneoma Onyenweaku, Tebekeme Okoko
    Am J Res Med Sci. 2018; 2(1): 17-23
    » Abstract » doi: 10.5455/ajrms.281421

  • Most Downloaded
  • Effect of antioxidant rich nutraceuticals on histological changes due to high fat diet induced obesity in rats
    Suleiman A. Isa, Muazu G. Abubakar, Muhammed S. Abubakar, Muhammad A. Ubana, Abdullahi Dandare
    Am J Res Med Sci. 2017; 1(1): 8-13
    » Abstract » doi: 10.5455/ajrms.281722

  • Primary Intracranial Myxoid Chondrosarcoma: A case report
    Hayam E. Rashed, Aziza E. Abdelrahman, Wael Elmesallamy, Ahmed A.E. Obaya
    Am J Res Med Sci. 2018; 2(1): 44-47
    » Abstract » doi: 10.5455/ajrms.281691

  • ROLE OF MELATONIN IN AMELIORATING CYTOTOXIC EFFECT OF GOLD NANOPARTICLES ON THE PULMONARY ALVEOLI OF ADULT ALBINO RATS.
    Ehab Mostafa Elzawawy, Abeer Gaber Ahmed
    Am J Res Med Sci. 2018; 2(1): 24-33
    » Abstract » doi: 10.5455/ajrms.281645

  • Study of Keratinocyte Proliferation, Apoptosis and Dermal Inflammation in Psoriatic Skin Lesions Before and After Methotrexate Therapy: Which Change Is Contributing More to Clinical Severity of the Disease?
    Amany Abdel Bary, Ahmed Abdel Bary
    Am J Res Med Sci. 2018; 2(1): 34-43
    » Abstract » doi: 10.5455/ajrms.281926

  • An in vitro screening study of food functions among vegetable cultivars consumed in Japan
    Naoki Ohkura, Riko Fujita, Ruri Kanai, Kenichi Ishibashi, Hiroshi Ueda, Gen-ichi Atsumi
    Am J Res Med Sci. 2018; 3(1): 1-6
    » Abstract » doi: 10.5455/ajrms.20180126090406

  • Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats
    Oluwatobi T Somade, Regina N Ugbaja, Abdullahi A Adebayo
    Am J Res Med Sci. 2017; 1(1): 27-34
    » Abstract » doi: 10.5455/ajrms.281388

  • Acute and sub-chronic oral toxicity studies on the methanol leaf extract of Gnetum africanum Welw in wistar rats.
    Nkeiruka Emmanuela Udeh, Aruh Anaga, Isaac Uzoma Asuzu
    Am J Res Med Sci. 2018; 3(1): 7-14
    » Abstract » doi: 10.5455/ajrms.20180109094114

  • Organ-Specific Effects of Selenium Glutathione Peroxidases in Response to Medicinal Plant Extracts
    Janka Vašková, Gabriela Moj& 382;išová, Ladislav Vaško, Michal Stanko, Janka Porá& 269;ová
    Am J Res Med Sci. 2018; 2(1): 1-8
    » Abstract » doi: 10.5455/ajrms.281449

  • Antioxidant evaluation and inhibitory activity of Chromolaena odorata leaf extract on hydrogen peroxide-induced erythrocyte hemolysis
    Angela Nwachukwu, Chioma Peace Iyagbo, Juliet Nneoma Onyenweaku, Tebekeme Okoko
    Am J Res Med Sci. 2018; 2(1): 17-23
    » Abstract » doi: 10.5455/ajrms.281421

  • Paracetamol and Hydrogen peroxide-induced tissue alterations are reduced by Costus afer extract
    Tebekeme Okoko
    Am J Res Med Sci. 2018; 2(2): 66-72
    » Abstract » doi: 10.5455/ajrms.20171230100944

  • Most Cited Articles