Peer-reviewed medical journal Vol. 11 • Issue 1

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American Journal of Medical and Clinical Sciences

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Volume 11

Issue 1 • 2026-02

1.387 Impact factor
Open Access model

Article details

An Unusual Case of Triple Synchronous Malignancies in a Middle-Aged Male Smoker: A Case Report and a Brief Literature Review.

Mark Bannon, Creticus Marak, Stephen T Bastible, Adrita Ashraf, Achuta Kumar Guddati, Prashant Kaushik.

Abstract

The presence of multiple primary malignant tumors (MPMTs) in a single individual is unusual. Depending on when the tumors are diagnosed, they can be classified as synchronous or metachronous. In the literature, metachronous tumors are more frequently described than synchronous ones. The vast majority of synchronous tumor cases involve two primary tumors, usually located in the same anatomic location, such as the prostate and bladder; or esophagus and stomach – organs that have been subject to field cancerization. A triple synchronous tumor arising in different anatomical locations is extremely rare. We present a unique case of a middle-aged man with synchronous lung, esophageal, and renal cancers.