E-ISSN 2576-3288


American Journal of Research in Medical Sciences. 2018; 2(2):(17-55)


Cerebral blastomycosis in a Tunisian woman

Ahlem Bdioui, Nihed Abdessayed, Nozha Mhamdi, Marwa Guerfela, Atef Ben Abdelkader, Moncef Mokni

Abstract
Background: Blastomycosis is a non-opportunistic fungal infection caused by Blastomyces dermatitides. Infection of the central nervous system is an uncommon localization of this disease occurring only in 5–10% of cases.
Case report: We report a new case of a 57-year-old woman, who was admitted in the neurosurgical department for severe headache, vomiting, and a visual disturbance. Physical and biological investigations were normal. Magnetic resonance imaging led to find an intracranial and extracranial expansive processes, measuring 42 mm in length. The microscopic examination revealed a chronic granulomatous inflammation, associating epithelioid and multinucleated giant cells containing thick-walled budding yeast-like forms. Grocott-Gomori methenamine–silver staining led to confirm its fungal nature, and it was precisely Blastomyces dermatitidis. The postoperative course was complicated by cerebral edema associated with an important cerebral hemorrhage. The patient died 11 days after the surgery.
Conclusion: Cerebral involvement remains a serious but uncommon manifestation of blastomycosis. It should be suspected in front of a granulomatous inflammation with the presence of spore on the pathological examination. The delay in diagnosis has been reported to play a significant role in the high mortality rate.
Most Viewed Article
  • Social Emotional Support on One-on-One and Group Family WhatsApp. Do Gender Differences Exist?
    Katzman Bat, Niva Dolev and Koslowsky Meni
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Secreted Protein Acidic and Rich in Cysteine (SPARC) and Chemokine’s mRNA expression in Endometrial Cancer versus Normal Endometrium: A Possible Pattern of Haematogenous and Lymphovascular Metastases
    Raffaella Giannice and Roberto Tozzi
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Can we Predict Lung Involvement by Laboratory Markers in Covid-19 Patients
    Naıme Almıla Ayhan Ceylan, Ebru Bıyıklı and Murat Muratoglu
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Treatment of Cutaneous Photoaging of Glabella with Autologous Platelet Concentrate
    Israel Alfonso Trujillo, Yetter Cruz Leon, Yudy Alvear Carvajal, Melissa Johana Espitia Cordero, Yaquelin Luciana Morales Novo, Angela Rosa Gutierrez Rojas, Jesus Lazaro Diego De la Campa, Julio Antonio López Silva, Daymi Serpa Almaguer
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Perceived Adverse Drug reactions to Artemether Lumefantrine and Artesunate Amodiaquine in Lagos, Nigeria
    Bamgboye M. Afolabi and Abiodun Ogunwale
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

Most Downloaded
  • Social Emotional Support on One-on-One and Group Family WhatsApp. Do Gender Differences Exist?
    Katzman Bat, Niva Dolev and Koslowsky Meni
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Secreted Protein Acidic and Rich in Cysteine (SPARC) and Chemokine’s mRNA expression in Endometrial Cancer versus Normal Endometrium: A Possible Pattern of Haematogenous and Lymphovascular Metastases
    Raffaella Giannice and Roberto Tozzi
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Can we Predict Lung Involvement by Laboratory Markers in Covid-19 Patients
    Naıme Almıla Ayhan Ceylan, Ebru Bıyıklı and Murat Muratoglu
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Treatment of Cutaneous Photoaging of Glabella with Autologous Platelet Concentrate
    Israel Alfonso Trujillo, Yetter Cruz Leon, Yudy Alvear Carvajal, Melissa Johana Espitia Cordero, Yaquelin Luciana Morales Novo, Angela Rosa Gutierrez Rojas, Jesus Lazaro Diego De la Campa, Julio Antonio López Silva, Daymi Serpa Almaguer
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Perceived Adverse Drug reactions to Artemether Lumefantrine and Artesunate Amodiaquine in Lagos, Nigeria
    Bamgboye M. Afolabi and Abiodun Ogunwale
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx