American Journal of Medical and Clinical Sciences. 2021; 6(4):(56-68)


Evaluation of Inferior Mesenteric Superior Lymph Node Metastasis in Early-Stage Endometrium Cancer and Its Clinical Significance

Dr. Esra CABUK COMERT

Abstract

Endometrial cancer is the fourth most common type of cancer in women cancers. In the light of projections, approximately 11,000 deaths occur annually in the USA alone. Lymph node metastasis is the most important prognostic factor in endometrial cancer. The aim of this study is to investigate the clinical and histopathological risk factors affecting lymph ode involvement.

The study included 30 randomly selected women from external centers who applied to our clinic with a preliminary diagnosis of endometrial cancer and were diagnosed with endometrial cancer in our clinic. The study group was divided into two groups as stage I (early stage) and stage II and above (advanced stage) according to the stages. Total abdominal hysterectomy (Type II), bilateral salpingo-oophorectomy, paraaortic lymph node dissection from the pelvic and IMA to the level of the left renal vein, omentectomy, and peritoneal cytology sampling were performed on each of the endometrial cancer participants.

The mean number of lymph node involvement in 30 patients in the study group was 45.9±15.1. The mean number of pelvic lymph nodes involved was 32.1±10.1, while the mean number of paraaortic lymph nodes involved was 13.9±6.9. As a result of the examinations, the highest number of Stage Ia was found. The frequency of endometrial adenocarcinoma was 80% and it was seen in 24 people. The mean tumor size, myometrial thickness, and depth of invasion of the patients were 2.97(±1.6), 1.57(±0.6), and 0.7(±0.6), respectively. With positive sub-IMA lymph node involvement, lymph node positivity was also detected in the area extending from the IMA to the level of the renal vein. It has been shown that the non-endomethroid tumor type detected in this group, myometrial invasion of more than 50%, grade 3 tumor and the presence of lymphovascular invasion affect lymph node involvement above the IMA.

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