E-ISSN 2576-3288


American Journal of Research in Medical Sciences. 2018; 2(2):(16-49)


Antioxidant enzymes and minerals status of diabetic subjects supplemented with antioxidant rich supplement (Alphabetic)

Abdullahi Yahya Abbas, Zaharadeen Abdullahi, Yusuf Saidu, Anas Ahmad Sabir, Mukhtar Jangebe Ladan, Francisca Chinyere Ikeonu, Mahmood Hassan Dalhat

Abstract
Objective: Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that oxidative stress plays a role in the pathogenesis of DM and its complications. The present study examines the effects of antioxidant rich supplement (Alphabetic) on antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] and minerals [Selenium (Se), Copper (Cu), Zinc (Zn), Manganese (Mn), and Chromium (Cr)] status of one hundred (100) diabetic subjects attending Usmanu Danfodiyo University Teaching Hospital for at least one year and the results were compared with those of fifty (50) non-supplemented diabetic subjects and fifty (50) apparently healthy non-diabetic subjects.
Methods: CAT activity was assessed using chemical reactivity method. SOD and GPx activities were assessed using Cayman’s Assay Kits according to manufacturer’s instructions. Antioxidant Minerals Levels were estimated by atomic absorption spectroscopy.
Results: The results revealed that the supplementation with Alphabetic significantly (P < 0.05) increased SOD, CAT, GPx activities and also increased the blood levels of Se, Zn, Mn, and Cr compared with the non-supplement group. Conclusion: These findings suggested that supplementation with antioxidant rich supplements might reduce the risk of oxidative stress associated with DM complications.
Most Viewed Article
  • High Medical Risk and Low Criminogenic Risk: What is the Price?
    Vasiliki Georgoulas-Sherry and Hanna G. Hernandez
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Investigating the Link between Irregular Muscle Tension and Bodily Fatigue among High- Speed String Instrument Musicians
    Hiroshi Tanabe, Hirofumi Tanabe, Toshimasa Mikawa and Yuichi Takata
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • A Risk Score Proposal for Covid-19 in Nursing Homes
    Ambra Raimondi MD, Gianluigi Poma MD, Domenico Zanaboni MD, Carolina Dellafiore MD, Elisabetta Above MD, Andrea Agostinelli MD, Catherine Klersy MD, Virginia Valeria Ferretti PhD, Anna Maria Grugnetti PhD, Andrea Falconeri MD, Vittoria Infantino MD, Lorena Sega MD, Valeria Meroni PhD, Antonio Piralla PhD, Fausto Baldanti MD and Carlo Filice MD
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • WISQ (Women in Surgery Questionnaire): A Glimpse at the Caribbean Perspective
    Calderon C, Maraj A, Roopnarine C and Crichlow J
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Risk of malnutrition in pulmonary fibrosis outpatients
    Botilla Dalsgaard Jensen (BJ) Stud. MSc, Sabina Mikkelsen (SM), MSc, Pernille Høyrup Krogh (PK) Stud. MSc, Christina Hornskov Lyngholm (CL) Stud. MSc, Jasmina Huremovic (JH), Consultant, MD and Mette Holst (MH), MCN, Ph.D
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

Most Downloaded
  • High Medical Risk and Low Criminogenic Risk: What is the Price?
    Vasiliki Georgoulas-Sherry and Hanna G. Hernandez
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Investigating the Link between Irregular Muscle Tension and Bodily Fatigue among High- Speed String Instrument Musicians
    Hiroshi Tanabe, Hirofumi Tanabe, Toshimasa Mikawa and Yuichi Takata
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • A Risk Score Proposal for Covid-19 in Nursing Homes
    Ambra Raimondi MD, Gianluigi Poma MD, Domenico Zanaboni MD, Carolina Dellafiore MD, Elisabetta Above MD, Andrea Agostinelli MD, Catherine Klersy MD, Virginia Valeria Ferretti PhD, Anna Maria Grugnetti PhD, Andrea Falconeri MD, Vittoria Infantino MD, Lorena Sega MD, Valeria Meroni PhD, Antonio Piralla PhD, Fausto Baldanti MD and Carlo Filice MD
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • WISQ (Women in Surgery Questionnaire): A Glimpse at the Caribbean Perspective
    Calderon C, Maraj A, Roopnarine C and Crichlow J
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx

  • Risk of malnutrition in pulmonary fibrosis outpatients
    Botilla Dalsgaard Jensen (BJ) Stud. MSc, Sabina Mikkelsen (SM), MSc, Pernille Høyrup Krogh (PK) Stud. MSc, Christina Hornskov Lyngholm (CL) Stud. MSc, Jasmina Huremovic (JH), Consultant, MD and Mette Holst (MH), MCN, Ph.D
    » Abstract » doi: 10.5455/ajrms:xxxxxxxxxxxxxx