E-ISSN 2576-3288
 

Original Research 


EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan.

Abstract
Objective: Sickle cell anemia (SCA) is one of the leading causes of child morbidity and mortality in Nigeria. About 25 % of the country’s population are carriers of the mutant gene responsible for the disease. Free radicals promote irreversible sickling of red blood cells (RBC) and damage its membrane. This study was designed to evaluate the effect of camel milk administration on oxidative stress biomarkers in sickle cell anemia patients.
Methods: 45 children aged 5 - 15 years old were recruited for the study. The patients were randomly divided into 3 groups, (i) HbAA: control group administered with 10 ml/kg of camel milk, (ii) HbSS-1: SCA subject administered with routine SCA drugs, (iii) HbSS-2: SCA administered with SCA drugs plus 10 ml/kg of camel milk.
Results: It was observed that three weeks of camel milk administration had resulted in significant changes in oxidative stress biomarkers. Serum level of GSH, vitamin C and E were significantly increased (P<0.05) in HbAA and HbSS-2 subject compared to HbSS-1. Similarly the activities of antioxidant enzymes (SOD and Catalase) were increased due to the camel milk administration. On the other hand, serum MDA level decreases in all the groups investigated (HbAA, HbSS-1 and HbSS-2). MDA level significantly decreased in HbSS-2 at the 3rd week of camel milk administration compared to other groups.
Conclusion: These findings suggest that camel milk could be beneficial in decreasing oxidative stress by improving the activities of antioxidant enzymes, and increasing the level of non enzymatic antioxidants in SCA patients. Thus camel milk could be used in relieving the conditions of SCA patients.

Key words: Camel milk, Sickle cell anemia, antioxidants, Oxidative stress.


 
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Pubmed Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan. EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.. Am J Res Med Sci. 2018; 3(1): 27-35. doi:10.5455/ajrms.20180422122959


Web Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan. EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.. http://www.ajrms.com/?mno=297312 [Access: December 09, 2018]. doi:10.5455/ajrms.20180422122959


AMA (American Medical Association) Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan. EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.. Am J Res Med Sci. 2018; 3(1): 27-35. doi:10.5455/ajrms.20180422122959



Vancouver/ICMJE Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan. EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.. Am J Res Med Sci. (2018), [cited December 09, 2018]; 3(1): 27-35. doi:10.5455/ajrms.20180422122959



Harvard Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan (2018) EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.. Am J Res Med Sci, 3 (1), 27-35. doi:10.5455/ajrms.20180422122959



Turabian Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan. 2018. EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.. American Journal of Research in Medical Sciences, 3 (1), 27-35. doi:10.5455/ajrms.20180422122959



Chicago Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan. "EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.." American Journal of Research in Medical Sciences 3 (2018), 27-35. doi:10.5455/ajrms.20180422122959



MLA (The Modern Language Association) Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan. "EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.." American Journal of Research in Medical Sciences 3.1 (2018), 27-35. Print. doi:10.5455/ajrms.20180422122959



APA (American Psychological Association) Style

Aminu Lailaba Abubakar, Saudatu Faruk, Abdullahi Dandare, Murtala M Ahmad, Muktari Jangebe Ladan (2018) EFFECT OF CAMEL MILK ADMINISTRATION ON OXIDATIVE STRESS IN SICKLE CELL ANEMIC PATIENTS.. American Journal of Research in Medical Sciences, 3 (1), 27-35. doi:10.5455/ajrms.20180422122959





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