American Journal of Medical and Clinical Sciences. 2018; 2(2):(16-71)


Antioxidant enzymes and minerals status of diabetic subjects supplemented with antioxidant rich supplement (Alphabetic)

Abdullahi Yahya Abbas, Zaharadeen Abdullahi, Yusuf Saidu, Anas Ahmad Sabir, Mukhtar Jangebe Ladan, Francisca Chinyere Ikeonu, Mahmood Hassan Dalhat

Abstract
Objective: Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that oxidative stress plays a role in the pathogenesis of DM and its complications. The present study examines the effects of antioxidant rich supplement (Alphabetic) on antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] and minerals [Selenium (Se), Copper (Cu), Zinc (Zn), Manganese (Mn), and Chromium (Cr)] status of one hundred (100) diabetic subjects attending Usmanu Danfodiyo University Teaching Hospital for at least one year and the results were compared with those of fifty (50) non-supplemented diabetic subjects and fifty (50) apparently healthy non-diabetic subjects.
Methods: CAT activity was assessed using chemical reactivity method. SOD and GPx activities were assessed using Cayman’s Assay Kits according to manufacturer’s instructions. Antioxidant Minerals Levels were estimated by atomic absorption spectroscopy.
Results: The results revealed that the supplementation with Alphabetic significantly (P < 0.05) increased SOD, CAT, GPx activities and also increased the blood levels of Se, Zn, Mn, and Cr compared with the non-supplement group. Conclusion: These findings suggested that supplementation with antioxidant rich supplements might reduce the risk of oxidative stress associated with DM complications.
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