American Journal of Medical and Clinical Sciences. 2018;
3(2):(27-148)
Interaction of nanoparticles with central nervous system and its consequences
Sairanthry Suku Athira, Nadukkandy Prajitha, Parayanthala Valappil Mohanan
Abstract
Nanotechnology has gained a non-replaceable role in a host of applications in biomedical,
agricultural, consumer, military, and in industrial sectors. However, when observed
through the perspective of the central nervous system (CNS) particularly, studies
evidently provide data on both beneficial and detrimental effects of nanoparticles
(NPs). While there exist a milieu of beneficial applications like axonal regeneration,
CNS imaging, neurological surgeries etc., NPs open the doorway for an array of toxic
reactions in CNS centers because of their effortless passage through brain barriers. Even
though literature endow with generalized toxic mechanisms mediated by NPs in varying
tissues, specific toxic reactions in CNS are still lacking. Present review mainly focuses on
different routes through which NPs get access into the brain and certain modes of toxic
mechanisms exhibited by NPs in CNS. A number of applications of NPs in the diagnosis
and treatment of CNS disorders also will be reviewed in concise.
