American Journal of Medical and Clinical Sciences. 2021; 6(3):(52-102)


Treatment of Cutaneous Photoaging of Glabella with Autologous Platelet Concentrate

Israel Alfonso Trujillo, Yetter Cruz Leon, Yudy Alvear Carvajal, Melissa Johana Espitia Cordero, Yaquelin Luciana Morales Novo, Angela Rosa Gutierrez Rojas, Jesus Lazaro Diego De la Campa, Julio Antonio López Silva, Daymi Serpa Almaguer

Abstract

Introduction: Platelet rich plasma (PRP) is an autologous blood product obtained after centrifugation of the blood. Contains high concentrations of platelets and growth factors. It is currently a very popular therapy in dermatology; however, few studies objectively evaluate its efficacy.

Objective: To evaluate the efficacy and safety of intradermal microinjection of autologous platelet concentrate (APC) in the treatment of glabella rejuvenation.

Method: An observational, analytical and longitudinal study was carried out in 60 patients from the Hospital Clínico Quirúrgico: “Hermanos Ameijeiras”, in the period between March 1, 2017 and March 31, 2020. The treatment was applied monthly. for 1 year. The final evaluation was carried out 3 months after the end of the treatment.

Results: 60 women with an average age of 45 ± 4.3 years were treated. After treatment, there were significant changes in the Glogau Photo Damage Scale (P = 0.012), in the Photo numeric Scale for evaluating the severity of glabella wrinkles (P = 0.031) and in the Global Aesthetic Improvement Scale (P = 0.012). The adverse events found were pain, inflammation and ecchymosis. The degree of satisfaction reported by the patients was good (25.0%) and very good (75.0%) (P = 0.027).

Conclusions: The autologous platelet concentrate proved to be effective and safe in reducing the signs of skin aging in glabella, associated with a high degree of patient satisfaction.

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